VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Pangolin

Scientific Name: Manis javanica

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis

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Ebola virus

Family: Filoviridae

Receptor: CLEC4G

Receptor CLEC4G information

Summary: This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_0035 2021.04 10X Genomics Duodenum Normal 1482 Link
Vthunter_0036 2021.04 10X Genomics Esophagus Normal 24581 Link
Vthunter_0037 2021.04 10X Genomics Heart Normal 12958 Link
Vthunter_0038 2021.04 10X Genomics Kidney Normal 4481 Link
Vthunter_0039 2021.04 10X Genomics LargeIntestine Normal 3328 Link
Vthunter_0040 2021.04 10X Genomics Liver Normal 5694 Link
Vthunter_0041 2021.04 10X Genomics Lung Normal 13720 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of CLEC4G in human tissues   [NCBI]

Expression: Biased expression in liver (RPKM 17.2), lymph node (RPKM 6.5) and 4 other tissues

Protein expression of CLEC4G in human tissues   [Proteinatlas]